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      • Opioid use disorder should be treated as a chronic condition with longitudinal, team-based, patient-centered care. Similar to type 2 diabetes mellitus or hypertension, opioid use disorder has genetic, environmental, and behavioral causes; the disorder responds best to long-term treatment with medication supplemented by behavior therapies.
      www.aafp.org/pubs/afp/issues/2019/1001/p416.html
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  2. Sep 19, 2024 · Physicians should be aware of methods for screening and detection of opioid use in clinical settings. Evidence-based treatments include detoxification, maintenance therapy with a relapse prevention medication, and psychosocial treatment.

  3. The most effective treatments for opioid use disorder include the combined use of medication and behavioral treatment. These treatments are routinely provided on an outpatient basis, including primary care or at federally regulated opioid treatment programs.

    • Opioids’ Effect on Brain Chemistry
    • Access and Exposure
    • Genetics and Biology
    • Mental Health and Medical Conditions
    • Adverse Childhood Experiences

    The likelihood of developing dependence following opioid use is high compared with most other drugs. Opioids have high addiction potential because they activate powerful reward centers in your brain. Opioids trigger your brain to release endorphins. This neurotransmitterboth decreases your perception of pain and creates feelings of euphoria. Once t...

    Access to opioids is a particularly significant environmental risk factor. The availability and volume of prescription opioids, especially in North America, Western Europe and Australia, make them easier to access. Other factors that increase the extent of exposure and the opportunity for opioid use include: 1. Being prescribed opioids for pain. Ab...

    Researchers estimate that genetic factors are responsible for 40% to 60% of the vulnerability to any substance use disorder. If you have a first-degree relative (biological sibling or parent) with OUD, you’re more likely to develop it as well.

    Several studies have found that about half of people who experience a mental health condition during their lives will also experience a substance use disorder and vice versa. Overlapping factors such as genetic vulnerabilities, issues with similar areas of your brain and environmental influences cause both substance use disorders, such as OUD, and ...

    Adverse childhood experiences (ACEs) are strongly related to the development of a wide range of health issues throughout a person’s lifespan, including substance use disorders. Several family-related ACEs increase the risk of drug use during adolescence (and adulthood), including: 1. Poor quality of parent-child interactions and relationships. 2. P...

  4. Jun 3, 2021 · The first step in the therapeutic approach to OUD is assessing the level of intoxication and withdrawal risk. For OUD the most immediate clinical concern is for potential overdose and respiratory suppression. If an opioid-related overdose is suspected, then naloxone is the first-line treatment.

    • Joseph A Carley, Tyler Oesterle
    • 10.2147/IJGM.S295461
    • 2021
    • Int J Gen Med. 2021; 14: 2305-2311.
  5. Jan 17, 2024 · Introduction. Etiology. Epidemiology. Pathophysiology. History and Physical. Evaluation. Treatment / Management. Differential Diagnosis.

  6. Understanding optimal approaches to screening for, diagnosing, and managing opioid use disorder (OUD), a chronic medical illness defined by an inability to control opioid use despite consequences, is necessary to address this condition. 2

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