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Not the inexorable
- As it turns out, aging is not the inexorable, straightforward process we once thought it was. Our ideas of longevity and life expectancy have changed not only with medicine, but also with new views on history.
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Jan 15, 2024 · In this respect, it can be argued that aging is a physiological process as it occurs as an inexorable consequence of life. In addition, the origin of this process−likely associated with the molecular damage accumulated through life−explains why it is so widespread among living creatures.
- 10.3389/fragi.2024.1334261
- 2024
- Front Aging. 2024; 5: 1334261.
May 10, 2023 · Why we age has been debated for many years. There are two schools of thought. One is that it is the accidental but inexorable accumulation of damage to cells and biomolecules.
Nov 15, 2017 · As it turns out, aging is not the inexorable, straightforward process we once thought it was. Our ideas of longevity and life expectancy have changed not only with medicine, but also with new views on history.
- Abstract
- The Aging Process
- Age-Associated Diseases
- The Determinants of Longevity
- What Can Be perturbed?
- Masks and Cover-Ups
- Genes Do Not Govern Aging
- “Anti-Aging Medicine”: An Oxymoron
- Is Perturbation of The Aging Process Likely?
- Desirability and Probability
WE know of no intervention that will slow, stop, or reverse the aging process in humans. It is also doubtful that intervention in the aging process has been achieved in any other life form in view of the absence of a generally accepted definition of aging and precise markers to measure its rate of change. Whether anti-aging medicine is, or is not, ...
In biological systems, aging is a stochastic process that occurs systemically after reproductive maturity in animals that reach a fixed size in adulthood. It is caused by the escalating loss of molecular fidelity that ultimately exceeds repair capacity and increases vulnerability to pathology or age-associated diseases (1–3). The fundamental cause ...
The distinction between the aging process and age-associated diseases is based not on dictionary definitions but on several practical observations: Unlike any disease, age changes (a) occur in every multicellular animal that reaches a fixed size at reproductive maturity, (b) cross virtually all species barriers, (c) occur in all members of a specie...
The final distinction to be made is that between the aging process and the process of longevity determination. Potential longevity is determined by the energetics of all molecules present at and after the time of reproductive maturation. Thus, every molecule, including those that compose the machinery involved in turnover, maintenance, and repair, ...
Of the three aspects of the finitude of life, only one has been successfully manipulated to increase human life expectancy. That aspect is the elimination, delay, or resolution of disease. No one has demonstrated how the aging and longevity determining processes in humans can be manipulated to extend life expectancy. From 1900, when life expectancy...
As stated earlier, we know of no intervention that will slow, stop, or reverse the aging process in humans. This is a statement of incontrovertible fact based on the definition of aging provided above. However, the common belief that masking age changes is equivalent to intervening in the fundamental aging process continues to lead to enormous conf...
The widespread use of products and services that mask or correct the nonpathological aspects of the fundamental aging process is one reason why the public has been misled to believe that we are close to understanding the fundamental aging process and close to developing interventions. We are not. The belief that intervention in the aging process is...
The failure to distinguish between aging research (biogerontology) and research on age-associated diseases (geriatric medicine) has been, and still is, a source of many misunderstandings. These misunderstandings underlie most of the beliefs that support the notion of an “anti-aging medicine.” There is little evidence that this failure, with its far...
The belief, even among some gerontologists, that we are on the verge of intervening in the aging process in humans has become so widespread recently that several calls have been made to debate the value of doing so (13,14). They admonish us to engage in dialogues on the serious impact that having the ability to perturb the aging process in humans w...
Even if the aging process was found to be capable of manipulation, intervening in the process is rife with unintended negative consequences. If advocates of intervention would understand aging as distinguished from disease and the process of longevity determination, then the folly of intervention should become apparent (1). Of the three phenomena—a...
- Leonard Hayflick
- 2004
Mar 3, 2016 · “ There is a tendency to think that aging is an inexorable process, that it is something in the genes, and there is nothing you can do about it. This paper is saying that may not be true ...
Oct 1, 2024 · Key facts. All countries face major challenges to ensure that their health and social systems are ready to make the most of this demographic shift. In 2050, 80% of older people will be living in low- and middle-income countries. The pace of population ageing is much faster than in the past. In 2020, the number of people aged 60 years and older ...
Jun 17, 2021 · We probably cannot slow the rate at which we get older because of biological constraints, an unprecedented study of lifespan statistics in human and non-human primates has confirmed. The study set out to test the ‘invariant rate of ageing’ hypothesis, which says that a species has a relatively fixed rate of ageing from adulthood.
