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- Ageing shows a broad phylogenetic distribution but is not universal, as some species show no age-associated increase in mortality or decline in fertility 5. Thus, ageing cannot be explained simply as the inevitable result of biological wear-and-tear.
www.nature.com/articles/35041682
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Jan 14, 2024 · In this respect, it can be argued that aging is a physiological process as it occurs as an inexorable consequence of life. In addition, the origin of this process−likely associated with the molecular damage accumulated through life−explains why it is so widespread among living creatures.
Thus, this theory presents aging as an inexorable consequence of the biology of the taxa, being further modulated by the accumulation and selection of mutations (Wensink and
Dec 12, 2015 · One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.
- Race DiLoreto, Coleen T. Murphy
- 10.1091/mbc.E14-06-1084
- 2015
- 2015/12/12
Jul 20, 2022 · The goals of aging biology research are broad and ambitious—to understand how a multitude of genes, pathways and mechanisms at multiple scales contribute to declines in function, health and...
Jun 1, 2004 · In biological systems, aging is a stochastic process that occurs systemically after reproductive maturity in animals that reach a fixed size in adulthood. It is caused by the escalating loss of molecular fidelity that ultimately exceeds repair capacity and increases vulnerability to pathology or age-associated diseases (1–3).
- Leonard Hayflick
- 2004
Nov 9, 2000 · The evolutionary theory of ageing explains why ageing occurs, giving valuable insight into the mechanisms underlying the complex cellular and molecular changes that contribute to senescence.
Dec 16, 2022 · Aging is a ubiquitous biological process that results in a progressive and irreversible decline in physical function across all organ systems that is induced by the accumulation of damage in...
