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Mar 24, 2024 · The proportions of δ1 + and δ2 + γδ T cells among naïve T cells were normal in patients with pre-TCRα deficiency ( Fig. 3H ). Thus, pre-TCRα deficiency has different impacts on the thymic outputs of αβ and γδ T cells, impairing the production of αβ T cells and favoring the production of γδ T cells.
- 10.1126/science.adh4059
- 2024/03
May 4, 2024 · The patients had normal counts of Langerhans cells (LCs) and dermal macrophages in the skin but lacked dermal DCs. Thus, FLT3L is required for B cell and DC development in mice and humans. However, unlike its murine counterpart, human FLT3L is required for the development of monocytes but not NK cells.
Publication 8626. Abstract. 98 Authors. 1 Application. We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted over time, with normal memory αβ and high γδ T cell counts.
- Science
- 1 Mar 2024
Efficient differentia-tion into CD4+CD8+DP cells (mean, ~52% of CD45+CD56−cells),TCRab+CD3+SPcells(~23%), and TCRgd+CD3+cells (~1.8%) was observed. By contrast, after 5 weeks of culture, viability was much lower for the CD34+cells isolated from all three pre-TCRa–deficient patients (7 to 39%).
Dec 19, 2023 · Proteomic Analysis of Pediatric Hemophagocytic Lymphohistiocytosis: a Comparative Study with Healthy Controls, Sepsis, Critical Ill, and Active Epstein-Barr virus Infection to Identify Altered Pathways and Candidate Biomarkers. Xun Li.
IFN-α2a Therapy in Two Patients with Inborn Errors of TLR3 and IRF3 Infected with SARS-CoV-2. J Clin Immunol. 2021 Jan 3. doi: 10.1007/s10875-020-00933-0. Online ahead of print.
Apr 14, 2020 · First evidence of ruxolitinib efficacy for subcutaneous panniculitis-like T-cell lymphoma with hemophagocytic lymphohistiocytosis. Supporting rationale for ruxolitinib use, not more aggressive treatment, in this context, questioning this condition’s neoplastic nature.
