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The minimum bactericidal concentration (MBC) is the lowest concentration of an antibacterial agent required to kill a particular bacterium. It can be determined from broth dilution minimum inhibitory concentration (MIC) tests by subculturing to agar plates that do not contain the test agent.
Minimum bactericidal concentration (MBC): The lowest concentration of antibiotic that kills a specified proportion of the starting population within a fixed timeframe. For example, the MBC 99 is the concentration of antibiotic that kills 99% of the starting population at a predetermined time point.
Dec 29, 2021 · Marked intra-species differences were observed in the resistance of L. monocytogenes to the biocides and antibiotics. The MICs (ppm) for the biocides ranged between 1750 and 4500 for SH, 0.25 and 20.00 for BC, and 1050 and 1700 for PAA. Their MBCs (ppm) ranged from 2250 to 4500 for SH, 0.50 to 20.00 for BC, and 1150 to 1800 for PAA.
Minimum Inhibitory Concentration (MIC) is the lowest concentration (expressed as mg/L or μg/μL) of an antimicrobial agent that inhibits the visible in-vitro growth of microorganisms. The MIC test determines the antimicrobial activity of a test agent against a specific bacteria.
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The MBC is the lowest antibiotic concentration required to kill 99.9% of the initial inoculum (i.e., ≥3-log drop in CFU ml − 1) (Pankey and Sabath, 2004). Antimicrobials are usually regarded as bactericidal if the MBC is no more than four times the MIC.
May 20, 2024 · MBC vs. MIC: A Comparative Analysis. The Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) are the keystones of interpretation in the context of drug development and therapy. The difference between these MBC vs. MIC and how they impact the direction for the development of antimicrobial strategies will be ...
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How is MBC determined?
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What is minimum bactericidal concentration (MBC)?
The difference lies in the outcome at the specified concentration. MIC is the concentration at which bacteria cease to multiply and hence there is no visible growth in the culture. MBC is the concentration at which bacteria are killed. Therefore, MBC is a more stringent condition that not only stops growth but also leads to cell death.
