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    • Dual-Staining Outperforms Cytology for HPV-positive ... - NCI
      • In the latest analysis, dual staining was shown to be as effective as Pap cytology at identifying cervical precancer, while at the same time, dramatically reducing the number of women sent to follow-up. The authors conclude that “dual staining can safely replace Pap cytology as a triage strategy for primary HPV screening.”
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  2. Oct 11, 2018 · A new test, called dual stain, may help improve how doctors care for women who test positive for human papillomavirus (HPV) infection during routine cervical cancer screening, an NCI-led study has shown. HPV tests detect infections with the cancer-causing types of HPV.

  3. WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention: use of dual-stain cytology to triage women after a positive test for human papillomavirus (HPV). Geneva: World Health Organization; 2024

  4. Jul 10, 2023 · Dual stain identifies abnormal cells through biomarker staining of cervical cells collected during routine cervical cancer screening. It uses two biomarkers – p16 and Ki-67 – that, when found together, signal changes at the cellular level that indicate a transforming HPV infection.

  5. Mar 6, 2024 · Dual stain testing on Pap test samples identifies the presence of two proteins: p16 (brown) and Ki-67 (red). Cervical cancer is preventable through vaccination against human papillomavirus, screening, and clinical management of abnormal results.

  6. Apr 3, 2024 · Carolyn Kay, MD, discusses the latest ASCCP guidelines and the introduction of dual stain cytology for improved HPV detection and patient management, aiming to alleviate anxiety and enhance efficacy in cervical cancer prevention.

  7. Oct 11, 2018 · The test, called p16/Ki-67 dual stain, more accurately predicted whether an HPV-positive woman would go on to develop cervical precancer within five years, compared to a Pap test—the current standard for managing HPV-positive women.

  8. Jun 25, 2020 · Dual-stain testing has emerged as a way to more accurately predict the chance that a woman with a positive HPV test has precancerous cervical changes. The test measures the presence of two proteins, p16 and Ki-67, in cervical samples.

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