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2 days ago · Clinical pathway recommendations (CPR) are based on existing guidelines and deliver a short overview on how to deal with a specific diagnosis, resulting therapy and follow-up. In this paper we propose a methodology for developing CPRs for Pompe disease, a metabolic myopathy caused by deficiency of lysosomal acid alpha-glucosidase. The CPR document was developed within the activities of the ...
1 day ago · A recent randomized clinical trial by Ruiz Iban and colleagues 63 examined 124 patients with full thickness medium-to-large posterosuperior chronic rotator cuff tears and found that the retear rate in the patch augmentation group was 8.3% versus 25.8% in the control group. This was evaluated at 1 year follow-up.
4 days ago · Rosenberg told NBC News in May, after Trump’s conviction, that jail time was unlikely but possible considering the former president spent much of the trial insulting the judge and defying his ...
2 days ago · Based on this trial, drug-induced pneumonitis occurred in 1.7% of patients. A phase 1/2 clinical trial showed that when combined with rituximab, polatuzumab vedotin-piiq caused pneumonitis in 4.4% of patients, again highlighting the effect of concurrent therapies on rates of DRP with targeted oncologic therapies.
4 days ago · From 2017 to 2020, registration trial results were published for four integrating vector CD19-targeting CAR-T therapies: axicabtagene ciloleucel , tisagenlecleucel , lisocabtagene maraleucel , and brexucabtagene autoleucel . Over the course of these trials, valuable insight was gained into patient care and management of severe adverse events.
2 days ago · To understand mechanisms of resistance to mutant-selective KRAS inhibition in PDAC, we sequenced ctDNA from pretreatment (PT) and post-progression [end of therapy (EOT)] plasma samples obtained from a rare cohort of patients with KRAS G12C-mutant PDAC treated with KRAS G12C inhibitors, including patients who demonstrated resistance to adagrasib monotherapy on the KRYSTAL-1 trial (patients 1 ...
4 days ago · Purpose of Review The incidence of bacterial sexually transmitted infections (STI) continues to rise particularly among men who have sex with men (MSM). Doxycycline post-exposure prophylaxis (doxy-PEP) has emerged as a promising biomedical prevention strategy. This review aims to summarize the results of recent studies, highlight the current normative guidance on the use of doxy-PEP, and ...
